SINCE World War II, medical science has progressed to some stage where competitive medications are around for treat precisely the same ailment in numerous people. This isn’t nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). On this report, we shall go through the various factors that decide the selection of a particular drug.
Safety: The following sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is often a particular drug even when it has certain side-effects provided that the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the possibility side-effect of addiction.
* Long-term safety: directory could be safe in short-term treatment, but wait, how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals reply to make a different chemical, that have an effect that may harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of each other, have certain effects one or even more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This leads to an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually make the same relation to precisely the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both the medicine is more intense.
Tolerability: A drug could be effective and not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability must be taken into account. Efficacy: A drug just isn’t equally efficient at all patients. For instance, some patients with depression or panic disorders experience relief from escitalopram, but there are many that do not, who therefore must be prescribed a different anti-depressant. The rate of start of therapeutic action is a crucial the answer to be regarded as too.
Cost: Cost doesn’t imply the cost of buying a specific medicine alone. It must also cover the cost of treating a complication that may arise from utilizing a different drug. Example: In the one who insists on taking alcohol nevertheless has to be treated for depression is generally administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (like tricyclics) might cause a new overuse injury in such patients, which could demand a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram instead of a cheaper tricyclic in these patients.
Simple treatment: The simplest mode of administration is preferred. If there is a choice between a shot and oral administration, the latter is preferred when the efficacy of both the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key point to determine simple treatment.
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