SINCE World War II, medical science has progressed to a stage where competitive medications are available to treat the same ailment in different people. This is not almost brands (which is a trade issue) but generic drugs (which is a scientific issue). On this report, we shall glance at the various factors that decide picking a a particular drug.
Safety: The following sub-criteria have to be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is a particular drug regardless of whether it has certain side-effects provided that the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but have the possibility side-effect of addiction.
* Long-term safety: http://medicationdirectory.com could possibly be safe in short-term treatment, so how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and a lot of chemicals respond to make a different chemical, which has an effect that could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of each other, have certain effects on a single or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon for the metabolism. This causes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually produce the same impact on the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the medicines are more serious.
Tolerability: A medication could possibly be effective however, not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability have to be taken into account. Efficacy: A medication is just not equally efficient at all patients. As an example, some patients with depression or panic disorders experience relief from escitalopram, but there are many that do not, who therefore have to be prescribed another anti-depressant. The rate of onset of therapeutic action is a vital step to be considered too.
Cost: Cost does not necessarily mean the cost of acquiring a particular medicine alone. It will also cover the cost of management of a complication that could arise by using another drug. Example: In a individual that insists on taking alcohol but should be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another gang of anti-depressants (including tricyclics) might cause a brand new problem in such patients, which will have to have a different and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram instead of a cheaper tricyclic such patients.
Simple treatment: The easiest mode of administration is preferred. If you have an alternative between an injection and oral administration, the second is preferred if the efficacy of the modes can be compared. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are key point to choose simple treatment.
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