Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors based on each SARM’s chemical structure. Therefore, SARMs cause anabolic cellular activity while avoiding most of the unwanted side effects of available today given. SARMs are already studied in the treatments for breast cancer and cachexia and also have been utilized as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs.
Aim
Presenting the history, mechanisms, current and potential clinical applications, along with risks and advantages of SARMs.
Methods
A literature review was performed in MEDLINE while using terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and lean muscle mass. Both basic research and scientific studies were included.
Main Outcome Measure
To perform an assessment of peer-reviewed literature.
Results
Though there are currently no U.S. Drug and food Agency-approved indications for SARMs, investigators are exploring the potential uses of these compounds. Investigation has devoted to the pharmacokinetics and pharmacodynamics of those agents, demonstrating good availability which has a paucity of drug interactions. Early clinical tests have demonstrated potential uses for SARMs in the treatments for cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancer of the breast, with good results.
Conclusion
SARMs have a lot of possible clinical applications, with promise for your safe used in the treatment of cachexia, BPH, hypogonadism, breast cancer, and cancer of prostate.
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