SINCE World war 2, medical science has progressed to some stage where competitive medications are around to treat exactly the same ailment in numerous people. This isn’t just about brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall look at the various factors that decide picking a a selected drug.
Safety: The following sub-criteria has to be considered within the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is really a particular drug even though it’s got certain side-effects provided that the acuteness with the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but have the possible side-effect of addiction.
* Long-term safety: medicine may be safe in short-term treatment, but how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and many chemicals reply to develop a different chemical, which has an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of each other, have certain effects on one or even more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on due to the metabolism. This causes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually make the same relation to exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both prescription medication is more intense.
Tolerability: A medication may be effective but not tolerable by all patients. Example: Allergies to a particular drugs in certain people. Short-term and long-term tolerability must be looked at. Efficacy: A medication is not equally great at all patients. As an example, some patients with depression or panic attacks experience rest from escitalopram, but there are many that do not, who therefore must be prescribed another anti-depressant. The speed of beginning of therapeutic action is a crucial factor to be looked at too.
Cost: Cost does not always mean the price tag on buying a particular medicine alone. It should also cover the price tag on treating a complication that may arise while using another drug. Example: In a individual that insists on taking alcohol but has to be treated for depression is normally administered an SSRI drug as these drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (such as tricyclics) could cause a brand new problem in such patients, which could need a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than cheaper tricyclic in such patients.
Simplicity of treatment: The easiest mode of administration is preferred. If you have an alternative between an injection and oral administration, aforementioned is preferred when the efficacy of both modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are an important factor to decide simple treatment.
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